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Maria Casagrande-Santiago is a character featured in the Nickelodeon animated series The Casagrandes, originally introduced as a minor recurring character in its sister series, The Loud House. She is Bobby and Ronnie Anne Santiago's mother who works as a nurse. Prior to the events of The Casagrandes, Maria raised her kids as a single parent following her divorce (though she does still get along well with her ex-husband, Arturo), but disliked the fact that her job as a nurse meant she couldn't spend much time with her kids. Eventually, she transferred to the Great Lakes City hospital and, along with her kids, moved to the apartment building run by her parents, Rosa and Hector Casagrande.

Maria's only appearance in a Halloween production was The Casagrandes' second Halloween episode, "Curse of the Candy Goblin".

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